Koncept NDRI v léčbě deprese
| Title in English | NDRI concept in the treatment of depression |
|---|---|
| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | new antidepressants; noradrenaline and dopamine reuptake inhibitors; bupropion |
| Description | Accidental discovery of antidepressants and antipsychotics has changed the image of psychiatry. The development of psychopharmacology is further influencing this speciality. More specific and safer antidepressants led to the shift of diagnostic and treatment of depression to outpatiente departments and to primary care. The study of mechanism of their efficacy contributes to the search of common etiopathogenic factors of psychoic and somatic disorders. Nowadays, we have antidepressants, which specificallly influence neurotransmitters, élaying a significant role in dperession - noradrenaline, dopamine and serotonin. The deficit of individual neurotransmitters is associated with certain syndromes ( symptoms). In some patient we assume a more pronounced alteration of noradrenergic and/or dopaminergic system, in others an alteration of serotonergic system. A simple laboratory differentiation is not afvailable: that is why we base the diagnosis on present symptoms. Further the concept of noradrenaline and dopamine reuptake inhibitors is discussed. Finally, clinical experience with the only available NDRI - bupropion is summarised. |
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