Effect of ajmaline on transient outward current Ito in rat ventricular myocytes

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2005
Type	Article in Periodical
Magazine / Source	General Physiology and Biophysics
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	ajmaline; transient outward current; rat; frequency dependence
Description	The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage.
Related projects:	Quantitative analysis of effect of tubular system on electrical activity of cardiac cells Early diagnostics and treatment of cardiovascular diseases Early diagnostics of Cardiovascular Diseases