A gender-specific association between a novel A5495G variant in the endothelial nitrix oxide synthase gene (NOS3) and respiratory allergy in the Czech population

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Authors

IZAKOVIČOVÁ HOLLÁ Lydie STEJSKALOVÁ Andrea BUČKOVÁ Dana SCHÜLLER Marcel ZNOJIL Vladimír

Year of publication 2003
Type Article in Periodical
Magazine / Source Eur.Respir.J.
MU Faculty or unit

Faculty of Informatics

Citation
Field Genetics and molecular biology
Keywords NOS; gene; polymorphism; gender; association
Description Several studies suggest that abnormalities in nitrix oxide (NO) synthesis may contribute to the development of pulmonary diseases. We recently identified a novel variant within intron 4 of the NOS3 gene: A to G conversion at nucleotide position 5495. We have, therefore, performed a case-control study to investigate a plausible association between this polymorphism in the NOS3 gene and respiratory allergic diseases.
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