Interakce mutace M235T genu pro angiotenzinogen a mutace Taq1 8000 v genu pro endotelin-1 při vzniku esenciální hypertenze

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Title in English	Interaction of Mutations M?235T ATG and Taq1 8,000 in the Gene for Endothelin-1 at the Onset of Essential Hypertension
Authors	VAŠKŮ Anna SOUČEK Miroslav ZNOJIL Vladimír KUHROVÁ Viera TSCHÖPLOVÁ Svatava VÁCHA Jiří
Year of publication	2000
Type	Article in Periodical
Magazine / Source	Časopis lékařů českých
MU Faculty or unit	Faculty of Medicine
Citation
Field	Cardiovascular diseases incl. cardiosurgery
Description	The aim of the study was to prove the existence of double genotype coincidence of polymorphic candidate genes between normotensive and hypertensive subjects. A Czech population sample (398 subjects, 192 normotensives and 206 hypertensives) was genotyped at angiotensinogen (M235T) and endothelin-1 (G8002A ET-1)genes using PCR method. We proved interaction of two polymorphic variants of both genes in essential hypertension-the decrease of MT heterozygotes in (--)homozygotes (P=0.0025) and the increase of the alele (-) in MM homozygotes(P=0.0034).
Related projects:	Molecular pathophysiology of selected multigenic related to civilization diseases Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension Molecular pathophysiology of multigene diseases