Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content

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Authors	TORRISI Jacopo CHVOJKA Matúš JURČEK Pia Yasmine ZHANG Xinxin ZENG Huaqiang ŠINDELÁŘ Vladimír VALKENIER Hennie
Year of publication	2025
Type	Article in Periodical
Magazine / Source	Angewandte Chemie International Edition
MU Faculty or unit	Faculty of Science
Citation
web	https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754
Doi	http://dx.doi.org/10.1002/anie.202424754
Keywords	Supramolecular Chemistry; Anion transport; Anion Channels; Macrocycles; Bambusurils
Attached files	2483224.pdf
Description	Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Related projects:	CETOCOEN Excellence Czech Infrastructure for Integrative Structural Biology Chemical modification of bambusurils for adjusting their binding affinity and selectivity Národní infrastruktura chemické biologie RECETOX research infrastructure