AlphaFind — discover structure similarity across the proteome in AlphaFold DB

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Authors

GREŠOVÁ Katarína ŠPRINGEROVÁ Pavlína SLANINÁKOVÁ Terézia PROCHÁZKA David OĽHA Jaroslav ROŠINEC Adrián JÁNOŠOVÁ Miriama ČILLÍK Jakub PORUBSKÁ Jana SVOBODOVÁ Radka DOHNAL Vlastislav ANTOL Matej

Year of publication 2024
Type Conference abstract
MU Faculty or unit

Institute of Computer Science

Citation
Attached files
Description AlphaFind is a web-based search engine that allows for structure-based search of the entire AFDB. Uniprot ID, PDB ID, or Gene Symbol is accepted as input – AlphaFind will return the most similar proteins found within AlphaFold DB, with an option to perform additional search to extend and refine the results. The search results are grouped by their source organism and displayed along with their TM-Score and RMSD measures (relative to the query protein). If the result proteins are experimentally found, we provide all associated PDB IDs. The 3D visualizations of the structural overlap of the proteins are provided using NGL Viewer, and the additional filters at the top of the results table can be used to find specific organisms or Uniprot IDs.
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