MicroRNA-mediated regulation of neurotransmitter receptors in epilepsy: A systematic review

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Authors

SONAWANE Shivani Kishor VŠIANSKÝ Vít BRÁZDIL Milan

Year of publication 2024
Type Article in Periodical
Magazine / Source EPILEPSY & BEHAVIOR
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S1525505024002932?via%3Dihub
Doi http://dx.doi.org/10.1016/j.yebeh.2024.109912
Keywords Epilepsy; Micro RNA; Neurotransmitter receptors
Attached files
Description Background: Pathogenesis of epilepsy involves dysregulation of the neurotransmitter system contributing to hyper-excitability of neuronal cells. MicroRNA (miRNAs) are small non-coding RNAs known to play a crucial role in post-transcriptional regulation of gene expression. Methods: The present review was prepared following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, employing a comprehensive search strategy to identify and extract data from published research articles. Keywords suchas epilepsy, micro RNA (micro RNAs, miRNA, miRNAs, miR), neurotransmitters (specific names), and neurotransmitter receptors (specific names) were used to construct the query. Results: A total of 724 articles were identified using the keywords epilepsy, microRNA along with select neurotransmitter and neurotransmitter receptor names. After exclusions, the final selection consisted of 17 studies, most of which centered on glutamate and gamma-aminobutyric acid (GABA) receptors. Singular studies also investigated miRNAs affecting cholinergic, purinergic, and glycine receptors. Conclusion: This review offers a concise overview of the current knowledge on miRNA-mediated regulation of neurotransmitter receptors in epilepsy and highlights their potential for future clinical application.
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