Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects

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Authors

RYBNIKÁŘ Michal MALANÍK Milan ŠMEJKAL Karel ŠVAJDLENKA Emil SHPET Polina BABICA Pavel DALL´ACQUA Stefano SMIŠTÍK Ondřej JURČEK Ondřej TREML Jakub

Year of publication 2024
Type Article in Periodical
Magazine / Source International Journal of Molecular Sciences
MU Faculty or unit

Faculty of Pharmacy

Citation
Web https://www.scopus.com/record/display.uri?eid=2-s2.0-85189099535&origin=resultslist&sort=plf-f&src=s&sid=320f9f405f8d16c2e4ac1b9f901b35ff&sot=b&sdt=b&s=TITLE-ABS-KEY%28Dibenzocyclooctadiene+Lignans+from+Schisandra+chinensis+with+Anti-Inflammatory+Effects
Doi http://dx.doi.org/10.3390/ijms25063465
Keywords anti-inflammatory; antioxidant; dibenzocyclooctadiene; gap junction; lignan; Schisandra chinensis
Description Schisandra chinensis (Schisandraceae) is a medicinal plant widely used in traditional Chinese medicine. Under the name Wu Wei Zi, it is used to treat many diseases, especially as a stimulant, adaptogen, and hepatoprotective. Dibenzocyclooctadiene lignans are the main compounds responsible for the effect of S. chinensis. As a part of ongoing studies to identify and evaluate anti-inflammatory natural compounds, we isolated a series of dibenzocyclooctadiene lignans and evaluated their biological activity. Furthermore, we isolated new sesquiterpene 7,7-dimethyl-11-methylidenespiro[5.5]undec-2-ene-3-carboxylic acid. Selected dibenzocyclooctadiene lignans were tested to assess their anti-inflammatory potential in LPS-stimulated monocytes by monitoring their anti-NF-kappa B activity, antioxidant activity in CAA assay, and their effect on gap junction intercellular communication in WB-ras cells. Some S. chinensis lignans showed antioxidant activity in CAA mode and affected the gap junction intercellular communication. The anti-inflammatory activity was proven for (-)-gomisin N, (+)-gamma-schisandrin, rubrisandrin A, and (-)-gomisin J.
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