Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model

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Authors

HORSKÁ Kateřina SKREDE Silje KUČERA Jan KUZMÍNOVÁ Gabriela SUCHÝ Pavel MICALE Vincenzo RUDÁ Jana

Year of publication 2024
Type Article in Periodical
Magazine / Source CNS NEUROSCIENCE & THERAPEUTICS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1111/cns.14565
Doi http://dx.doi.org/10.1111/cns.14565
Keywords adipokine; antipsychotic; lipid profile; methylazoxymethanol; schizophrenia
Attached files
Description Our results demonstrate metabolic vulnerability in female prenatally MAM-exposed rats indicating that findings from healthy animals are likely to provide an underestimated impression of metabolic dysfunction associated with antipsychotics. In the context of metabolic disturbances, neurodevelopmental models possess a relevant background, and the search for adequate animal models should receive more attention within the field of experimental psychopharmacology.
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