Laser Ablation Inductively Coupled Plasma Mass Spectrometry as a Powerful Tool for Spatially Resolved Analysis: An Experiment for Undergraduate Analytical Chemistry Laboratory

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Authors

KUCHYNKA Michaela HOLCOVÁ POLANSKÁ Hana GUMULEC Jaromír KANICKÝ Viktor VACULOVIČ Tomáš

Year of publication 2023
Type Article in Periodical
Magazine / Source Journal of Chemical Education
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/10.1021/acs.jchemed.2c01111
Doi http://dx.doi.org/10.1021/acs.jchemed.2c01111
Keywords Upper-Division Undergraduate; Analytical Chemistry; Lasers; Mass Spectrometry; Quantitative Analysis
Description A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub mu g center dot g-1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student's task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.
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