Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.

Investor logo

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

ČERNOVSKÁ Karolína PORC Jakub Paweł ZÁVACKÁ Kristýna ONDROUŠKOVÁ Eva JAROŠOVÁ Marie POSPÍŠILOVÁ Šárka PLEVOVÁ Karla

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Attached files
Description The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.