Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

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Authors

GONZÁLEZ LÓPEZ Marcos HUTEČKOVÁ Barbora LAVICKÝ Josef ZEZULA Nikodém RAKULTSEV Vladislav FRIDRICHOVÁ Vendula TUAIMA Haneen Riadh Ali NOTTMEIER Cita PETERSEN Julian KAVKOVÁ Michaela ZIKMUND Tomas KAISER Jozef LAV Rupali STAR Haza BRYJA Vítězslav HENYŠ Petr VOŘECHOVSKÝ Miroslav TUCKER Abigail S S HARNOŠ Jakub BUCHTOVÁ Marcela KŘIVÁNEK Jan

Year of publication 2023
Type Article in Periodical
Magazine / Source Science Advances
MU Faculty or unit

Faculty of Medicine

Citation
Web https://doi.org/10.1126/sciadv.adi0482
Doi http://dx.doi.org/10.1126/sciadv.adi0482
Keywords hard tissue development; spatiotemporal monitoring; tooth and bone development
Attached files
Description Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.
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