MAIA; Fc receptor-like 3; supersedes JUNO as IZUMO1 receptor during human fertilization

Investor logo
Investor logo

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

VONDRAKOVA Jana FROLIKOVA Michaela DED Lukas CERNY Jiri POSTLEROVA Pavla PALENIKOVA Veronika SIMONIK Ondrej NAHACKA Zuzana BASUS Krystof VALASKOVA Eliska MACHAN Radek PACEY Allan HOLUBCOVÁ Zuzana KOUBEK Pavel EZROVA Zuzana PARK Soojin LIU Ruiwu PARTHA Raghavendran CLARK Nathan NEUZIL Jiri IKAWA Masahito ERICKSON Kent LAM Kit S. MOORE Harry KOMRSKOVA Katerina

Year of publication 2022
Type Article in Periodical
Magazine / Source Science advances
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.science.org/doi/10.1126/sciadv.abn0047
Doi http://dx.doi.org/10.1126/sciadv.abn0047
Keywords human fertilization; MAIA; Fc receptor-like 3; supersedes JUNO; IZUMO1
Description Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.