Prediction of Vagal Nerve Stimulation Efficacy in Drug-Resistant Epilepsy (PRECISE): Prospective Study for Pre-implantation Prediction/Study Design

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Authors

DOLEŽALOVÁ Irena KORIŤÁKOVÁ Eva SOUČKOVÁ Lenka CHRASTINA Jan CHLÁDEK Jan ŠTĚPÁNOVÁ Radka BRÁZDIL Milan

Year of publication 2022
Type Article in Periodical
Magazine / Source FRONTIERS IN NEUROLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://pubmed.ncbi.nlm.nih.gov/35386419/
Doi http://dx.doi.org/10.3389/fneur.2022.839163
Keywords drug-resistant epilepsy; efficacy prediction; statistical model; study design; vagal nerve stimulation.
Description Vagal nerve stimulation (VNS) can be indicated in patients with drug-resistant epilepsy, who are not eligible for resective epilepsy surgery. In VNS therapy, the responder rate (i.e., percentage of subjects experiencing ?50% seizure reduction) is ~50%. At the moment, there is no widely-accepted possibility to predict VNS efficacy in a particular patient based on pre-implantation data, which can lead to unnecessary surgery and improper allocation of financial resources. The principal aim of PRediction of vagal nerve stimulation EfficaCy In drug-reSistant Epilepsy (PRECISE) study is to verify the predictability of VNS efficacy by analysis of pre-implantation routine electroencephalogram (EEG).
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