Cyanine-flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions

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Authors	YANG Qiuyun MUCHOVA Lucie ŠTACKOVÁ Lenka ŠTACKO Peter ŠINDELÁŘ Vladimír VÍTEK Libor KLÁN Petr
Year of publication	2022
Type	Article in Periodical
Magazine / Source	Chemical Communications
MU Faculty or unit	Faculty of Science
Citation
Web	https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC02648A
Doi	http://dx.doi.org/10.1039/d2cc02648a
Keywords	MECHANISMS; MOLECULES; ACID; DYES
Description	Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.
Related projects:	CETOCOEN Excellence CETOCOEN Excellence RECETOX RI Flavonoidy jako unikátní třída molekul fotochemicky uvolňujících oxid uhelnatý