Cyanine-flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	YANG Qiuyun MUCHOVA Lucie ŠTACKOVÁ Lenka ŠTACKO Peter ŠINDELÁŘ Vladimír VÍTEK Libor KLÁN Petr
Year of publication	2022
Type	Article in Periodical
Magazine / Source	Chemical Communications
MU Faculty or unit	Faculty of Science
Citation
web	https://pubs.rsc.org/en/content/articlelanding/2022/CC/D2CC02648A
Doi	http://dx.doi.org/10.1039/d2cc02648a
Keywords	MECHANISMS; MOLECULES; ACID; DYES
Description	Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.
Related projects:	CETOCOEN Excellence CETOCOEN Excellence RECETOX RI Flavonoidy jako unikátní třída molekul fotochemicky uvolňujících oxid uhelnatý