The Use of Confocal Laser Endomicroscopy in Diagnosing Barrett’s Esophagus and Esophageal Adenocarcinoma

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Authors

VACULOVÁ Jitka KROUPA Radek KALA Zdeněk DOLINA Jiří GROLICH Tomáš VLAŽNÝ Jakub SAID Dávid IZAKOVIČOVÁ HOLLÁ Lydie BOŘILOVÁ LINHARTOVÁ Petra PROCHÁZKA Vladimír JOUKAL Marek JABANDŽIEV Petr SLABÝ Ondřej KUNOVSKÝ Lumír

Year of publication 2022
Type Article in Periodical
Magazine / Source Diagnostics
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2075-4418/12/7/1616
Doi http://dx.doi.org/10.3390/diagnostics12071616
Keywords confocal laser endomicroscopy; probe-based confocal laser endomicroscopy; diagnosis; Barrett’s esophagus; esophageal cancer; early esophageal adenocarcinoma
Description Confocal laser endomicroscopy (CLE) is a diagnostic technique that enables real-time microscopic imaging during microscopic examination and evaluation of epithelial structures with 1000-fold magnification. CLE can be used in the diagnosis of various pathologies, in pneumology, and in urology, and it is very widely utilized in gastroenterology, most importantly in the diagnosis of Barrett’s esophagus (BE), esophageal adenocarcinoma (EAC), biliary strictures, and cystic pancreatic lesions. A literature search was made in MEDLINE/PubMed and Google Scholar databases while focusing on diagnostics using CLE of BE and EAC. We then examined randomized and observational studies, systematic reviews, and meta-analyses relating to the utilization of CLE in BE and EAC diagnostics. Here, we discuss whether CLE can be a suitable diagnostic method for surveillance of BE. Even though many studies have proven that CLE increases diagnostic accuracy in detecting neoplastic transformation of BE, CLE is still not used as a standard diagnostic tool in BE surveillance due to a deficiency of scientific evidence. More studies and data are needed if CLE is to find a place as a new technique in BE surveillance.
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