Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study

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Authors

HELÁN Martin MALÁSKA Jan TOMANDL Josef JARKOVSKÝ Jiří HELÁNOVÁ Kateřina BENEŠOVÁ Klára ŠITINA Michal DASTYCH Milan ONDRÚŠ Tomáš PÁVKOVÁ GOLDBERGOVÁ Monika GÁL Roman LOKAJ Petr TOMANDLOVÁ Marie PAŘENICA Jiří

Year of publication 2022
Type Article in Periodical
Magazine / Source Antioxidants
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.mdpi.com/2076-3921/11/4/640
Doi http://dx.doi.org/10.3390/antiox11040640
Keywords sepsis; septic shock; oxidative stress; antioxidant; biomarker; soluble endoglin; superoxide dismutase; asymmetric dimethylarginine; neopterin
Description Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present pilot study, we have analysed eight oxidative-stress-related biomarkers in seven consecutive time points (i.e., the first seven days) in 21 septic shock patients admitted to the ICU. Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2'-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Furthermore, we analysed each biomarker’s ability to predict mortality at the time of admission and 12 h after admission. Although a small number of study subjects were recruited, we have identified four promising molecules for further investigation: soluble endoglin, superoxide dismutase, asymmetric dimethylarginine and neopterin.
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