Advances in Cancer Metabolism and Tumour Microenvironment
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| Year of publication | 2022 |
| Type | Article in Periodical (without peer review) |
| MU Faculty or unit | |
| Citation | |
| Description | Cancer represents an extremely complicated ecosystem where cancer cells communicate with non-cancer cells present in the tumour niche through intercellular contacts, paracrine production of bioactive factors and extracellular vesicles, such as exosomes. The non-cancer cells that participate in the control of biological properties of the malignant disease include cancer-associated fibroblasts (CAFs), tumour-associated macrophages, granulocytes, NK cells and subsets of lymphocytes . Differences in the metabolism of cancer cells were established many years ago, and the relationship between the tumour microenvironment (TME) and the metabolism was shown. Distinguished scientists have prepared highly instructive articles on this topic with the aim of gaining a deeper insight into the role of the microenvironment and the differences in the cancer cell metabolism to refine the diagnostics and propose new strategies for anticancer therapy. Tumour cells share the common ability to obtain necessary nutrients from a relatively poor environment and use them flexibly to maintain their viability and build new biomass. Bioenergetically demanding processes accompanying malignant transformation, such as rapid proliferation and the ability to migrate, require increased production of adenosine triphosphate (ATP), nucleic acids, proteins and lipids. The changes in intracellular and extracellular metabolites that accompany the metabolic reprogramming associated with tumour growth subsequently have a profound effect on gene expression, cellular differentiation and the tumour microenvironment. |
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