Depressive-like phenotype enhances relapse of nicotine seeking after forced abstinence in rats

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	AMCHOVÁ Petra RUDÁ Jana
Year of publication	2023
Type	Article in Periodical
Magazine / Source	The World Journal of Biological Psychiatry
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.tandfonline.com/doi/full/10.1080/15622975.2022.2070665
Doi	http://dx.doi.org/10.1080/15622975.2022.2070665
Keywords	abuse; depression; nicotine; olfactory bulbectomy; rats; self-administration
Description	Comorbidity of depression and drug addiction is common, but effective treatment is missing. A rat model combining the olfactory bulbectomy (OBX) model and IV drug self-administration has provided evidence of differential reactivity of the OBX rats towards drugs of abuse. This study evaluates nicotine taking and seeking behavior in this model.
Related projects:	Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii