Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

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Authors

COHEN-ADAD Julien ALONSO-ORTIZ Eva ABRAMOVIC Mihael ARNEITZ Carina ATCHESON Nicole BARLOW Laura BARRY Robert L BARTH Markus BATTISTON Marco BÜCHEL Christian BUDDE Matthew CALLOT Virginie COMBES Anna J E LEENER Benjamin De DESCOTEAUX Maxime SOUSA Paulo Loureiro de DOSTÁL Marek DOYON Julien DVORAK Adam EIPPERT Falk EPPERSON Karla R EPPERSON Kevin S FREUND Patrick FINSTERBUSCH Jürgen FOIAS Alexandru FRATINI Michela FUKUNAGA Issei WHEELER-KINGSHOTT Claudia A M Gandini GERMANI Giancarlo GILBERT Guillaume GIOVE Federico GROS Charley GRUSSU Francesco HAGIWARA Akifumi HENRY Pierre-Gilles HORÁK Tomáš HORI Masaaki JOERS James KAMIYA Kouhei KARBASFOROUSHAN Haleh KEŘKOVSKÝ Miloš KHATIBI Ali KIM Joo-Won KINANY Nawal KITZLER Hagen H KOLIND Shannon KONG Yazhuo KUDLIČKA Petr KUNTKE Paul KURNIAWAN Nyoman D KUSMIA Slawomir LABOUNEK René LAGANA Maria Marcella LAULE Cornelia LAW Christine S LENGLET Christophe LEUTRITZ Tobias LIU Yaou LLUFRIU Sara MACKEY Sean MARTINEZ-HERAS Eloy MATTERA Loan NESTRASIL Igor GRADY Kristin P O PAPINUTTO Nico PAPP Daniel PARETO Deborah PARRISH Todd B PICHIECCHIO Anna PRADOS Ferran ROVIRA Alex RUITENBERG Marc J SAMSON Rebecca S SAVINI Giovanni SEIF Maryam SEIFERT Alan C SMITH Alex K SMITH Seth A. SMITH Zachary A. SOLANA Elisabeth SUZUKI Y. TACKLEY George TINNERMANN Alexandra VALOŠEK Jan VILLE Dimitri Van De YIANNAKAS Marios C. WEBER Kenneth A. II. WEISKOPF Nikolaus WISE Richard G. WYSS Patrik O. XU Junqian

Year of publication 2021
Type Article in Periodical
Magazine / Source Scientific Data
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.nature.com/articles/s41597-021-00941-8
Doi http://dx.doi.org/10.1038/s41597-021-00941-8
Keywords spinal cord; reproducibility; MRI
Description In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.
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