NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	RUDÁ Jana AMCHOVÁ Petra ŠIŠKA Filip TIZABI Yousef
Year of publication	2021
Type	Article in Periodical
Magazine / Source	The World Journal of Biological Psychiatry
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.tandfonline.com/doi/full/10.1080/15622975.2021.1907714
Doi	http://dx.doi.org/10.1080/15622975.2021.1907714
Keywords	AMPA/kainate receptor; Nicotine; Methamphetamine; Self-administration; Relapse
Description	Pharmacological manipulations of glutamatergic ionotropic receptors have been suggested as a promising target for addiction treatment. Antagonists of AMPA/kainate receptors were shown to reduce alcohol intake or alcohol-seeking in various animal models. In this study, we evaluated the effect of NBQX, an AMPA/kainate receptor antagonist, on methamphetamine (METH) and nicotine self-administration in rats.
Related projects:	Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii Základní výzkum v oblasti farmakokinetiky, neurobiologie závislostí a aplikovaný výzkum v oblasti personalizované farmakoterapie v onkologii