Ozonization of Tissue Sections for MALDI MS Imaging of Carbon-Carbon Double Bond Positional Isomers of Phospholipids

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Authors	BEDNAŘÍK Antonín PREISLER Jan BEZDEKOVÁ Dominika MACHÁLKOVÁ Markéta HENDRYCH Michal NAVRÁTILOVÁ Jarmila KNOPFOVÁ Lucia MOSKOVETS Eugene SOLTWISH Jens DREISEWERD Klaus
Year of publication	2020
Type	Article in Periodical
Magazine / Source	Analytical Chemistry
MU Faculty or unit	Faculty of Science
Citation
web	https://pubs.acs.org/doi/abs/10.1021/acs.analchem.0c00641
Doi	http://dx.doi.org/10.1021/acs.analchem.0c00641
Keywords	ozonolysis; MALDI MS imaging; double bond positional isomers; phospholipids; colon
Description	A particular traightforward derivatization technique for an on-tissue ozonization that enables MALDI MS/MS imaging of C=C double bond isomers of unsaturated phospholipids in tissue sections was developed.
Related projects:	CEITEC 2020 Optimalizace cílené terapie kolorektálního karcinomu ovlivňováním účinnosti penetrace a cytotoxicity regulátorů buněčných signalizací MALDI MS zobrazování izomerů lipidů lišících se pozicí dvojné vazby uhlík-uhlík