Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog
| Authors | |
|---|---|
| Year of publication | 2019 |
| Type | Article in Periodical |
| Magazine / Source | BMC Veterinary Research |
| MU Faculty or unit | |
| Citation | |
| Web | https://bmcvetres.biomedcentral.com/track/pdf/10.1186/s12917-019-2154-8 |
| Doi | http://dx.doi.org/10.1186/s12917-019-2154-8 |
| Keywords | Canine; Clonality; Dog; Lymphoma; Lymphosarcoma; Antigen receptor gene rearrangement; PARR; Composite lymphoma |
| Description | Background Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality of lymphocyte antigen receptor genes. Case presentation An 8-year-old male intact Mastiff presented with generalized lymphadenomegaly was diagnosed with nodal T zone lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow cytometry. Thirteen months later, the dog re-presented with progressive lymphadenomegaly, and based on cytology and flow cytometry, a large B cell lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the de novo development of a LBCL and the persistence of a TZL. Conclusions The occurrence of two distinct lymphoid neoplasms should be considered if patient features and tumor cytomorphology or immunophenotype differ among sequential samples. Sequencing-based clonality testing may provide conclusive evidence of two concurrent and distinct clonal lymphocyte populations, termed most appropriately "composite lymphoma". |
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