Enhanced bioactivity of electrospun PCL and PLLA scaffolds blended with amino-phosphazene

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Authors	SEDLÁKOVÁ Veronika VORÁČ Zbyněk JAROŠ Josef KOPECKÁ Radka KLOUČKOVÁ Michaela SVOBODA Michal STREIT Libor DUMKOVÁ Jana VAŠÍČKOVÁ Kateřina ALBERTI Milan HAMPL Aleš
Year of publication	2018
Type	Article in Periodical
Magazine / Source	Materials Letters
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.sciencedirect.com/science/article/pii/S0167577X18309297?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.matlet.2018.06.023
Keywords	Phosphazene; Amino; Electrospinning; Biomaterials; Biomimetic; Morphology
Description	Here we report for the first time that blending hexaamino-cyclo-triphosphazene with either poly-epsilon-caprolactone or poly-L-lactic acid enables the generation of blended electrospun scaffolds with enhanced bioactivities. These hexaamino-cyclo-triphosphazene-modified fibers significantly promote cell adhesion, spreading, metabolism, and proliferation. In addition to that we also report more efficient hexaaminocyclo-triphosphazene synthesis with a higher yield and purity.
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