Cellular structural biology of nucleic acids
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The nucleic acid structure, particularly that of DNA, is sensitively modulated by non-specific physical and chemical environmental factors such as nucleic acids concentration, water activity, molecular crowding, viscosity, temperature, pH and/or concentration and nature of counter ions. Existence of environmentally promoted conformational polymorphism thus indicates that characterization of DNA structure, dynamics, and DNA-ligand/protein interactions should be ideally performed under native conditions in complex environment of living cells. |
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