Sensitive determination of SEVNL and DAEFR pentapeptides as beta-secretase products by CE-C4D for its activity assay

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Authors

MÁDR Aleš SCHEJBAL Jan GLATZ Zdeněk

Year of publication 2016
Type Article in Proceedings
Conference 13th International Interdisciplinary Meeting on Bioanalysis (CECE2016)
MU Faculty or unit

Faculty of Science

Citation
Web http://www.ce-ce.org
Field Biochemistry
Keywords beta-secretase; Alzheimer desease; CE; C4D
Attached files
Description Alzheimer’s disease is the most common form of dementia; however, effective treatment is not yet available. Mechanism of the disease involves formation of neurotoxic oligomers of beta-amyloid peptides. These peptides are produced mainly by beta-secretase thus inhibition of the enzyme might be a way to treat the disease. In order to study enzyme’s inhibition – preferably with unlabeled substrates – high method’s sensitivity is demanded. Consequently, highly sensitive capillary electrophoresis based method with contactless conductivity detection was developed.
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