The influence of chronic application of olazapine on brain perfusion in rat

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Authors

DRAŽANOVÁ Eva RUDÁ Jana GROSSOVÁ Lucie HORSKÁ Kateřina KOTOLOVÁ Hana BABINSKÁ Zuzana STARČUK Zenon

Year of publication 2016
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Olanzapin is a commonly used atypical antipsychotic drug. We hypothesize that long term therapy of olanzapin could alter region dependent blood brain perfusion, which we tested by arterial spin labeling (ASL) MR imaging. Statistical evaluation of the ASL results in the hippocampus, somatosensory cortex and piriform cortex revealed significantly lower somatosensory cortex perfusion in olanzapin-treated animals.
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