STUDYING OF COMPETITIVE INTERACTIONS OF DRUGS WITH HUMAN SERUM ALBUMIN BY CAPILLARY ELECTROPHORESIS-FRONTAL ANALYSIS

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Authors

NEVÍDALOVÁ Hana MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2016
Type Article in Proceedings
Conference 13 th International Interdisciplinary Meeting on Bioanalysis CECE 2016
MU Faculty or unit

Faculty of Science

Citation
Web Oficiální stránky konference
Field Biochemistry
Keywords capillary electrophoresis-frontal analysis; competitive interaction; albumin
Description Drug-protein interactions have a significant effect on pharmacodynamics and pharmacokinetics properties of drugs. Bound fraction of drugs is reservoir, whereas free fraction provides pharmacological effect.Study of drug-protein interactions is thus important in the clinical therapy and in the development of new drugs.In this study displacement of L tryptophan from its binding site on human serum albumin (HSA) by several drugs was investigated by capillary electrophoresis frontal analysis (CE-FA).
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