STUDYING OF COMPETITIVE INTERACTIONS OF DRUGS WITH HUMAN SERUM ALBUMIN BY CAPILLARY ELECTROPHORESIS-FRONTAL ANALYSIS
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | 13 th International Interdisciplinary Meeting on Bioanalysis CECE 2016 |
| MU Faculty or unit | |
| Citation | |
| Web | Oficiální stránky konference |
| Field | Biochemistry |
| Keywords | capillary electrophoresis-frontal analysis; competitive interaction; albumin |
| Description | Drug-protein interactions have a significant effect on pharmacodynamics and pharmacokinetics properties of drugs. Bound fraction of drugs is reservoir, whereas free fraction provides pharmacological effect.Study of drug-protein interactions is thus important in the clinical therapy and in the development of new drugs.In this study displacement of L tryptophan from its binding site on human serum albumin (HSA) by several drugs was investigated by capillary electrophoresis frontal analysis (CE-FA). |
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