(SALD) ICP-MS to examine the effect of copper on wedelolactone cytotoxicity towards breast cancer cells

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Authors

STIBOREK Marek NEHYBOVÁ Tereza BENEŠ Petr KANICKÝ Viktor PREISLER Jan

Year of publication 2016
Type Article in Proceedings
Conference CECE 2016 International Interdisciplinary Meeting on Bioanalysis
MU Faculty or unit

Faculty of Science

Citation
Field Analytic chemistry
Keywords SALD-ICP-MS-wedelolactone-cancer-cell
Description In this study, the effect of copper on wedelolactone cytotoxicity towards breast cancer cells was examined. To monitor copper loading of cells, SALD ICP-MS (substrate assisted laser desorption inductively coupled plasma mass spectrometry) and conventional nebulizing ICP-MS analysis were used. The SALD technique provided direct and fast analysis of liquid samples in the form of dried droplets with minimal sample preparation and sub-microliter sample volume requirement. Furthermore, the SALD allowed direct analysis of samples in organic solvents, which could not be directly nebulised to ICP-MS. The experiments showed that copper chelation can drastically reduce wedelolactone cytotoxicity.
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