Determination of interactions of human serum albumin and its glycated form with antidiabetic drugs by CE-FA

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Authors

MICHALCOVÁ Lenka GLATZ Zdeněk

Year of publication 2016
Type Article in Proceedings
Conference Advances in chromatography and electrophoresis, Chiranal 2016
MU Faculty or unit

Faculty of Science

Citation
Field Biochemistry
Keywords binding constant, capillary electrophoresis - frontal analysis, antidiabetic drugs, HSA
Attached files
Description The binding constants (Kb) of systems HSA or glycated HSA (gHSA) with antidaibetic drugs were determined by capillary electrophoresis – frontal analysis (CE-FA). Apparent Kb values were obtained by nonlinear regression analysis. The Kb of HSA-drug and gHSA-drug were compared. The Kb values of glycated form were lower than nonglycated albumin. This modification influences strenght of binding between gHSA and antibiabetc drugs.
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