Determination of interactions of human serum albumin and its glycated form with antidiabetic drugs by CE-FA
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Proceedings |
| Conference | Advances in chromatography and electrophoresis, Chiranal 2016 |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | binding constant, capillary electrophoresis - frontal analysis, antidiabetic drugs, HSA |
| Attached files | |
| Description | The binding constants (Kb) of systems HSA or glycated HSA (gHSA) with antidaibetic drugs were determined by capillary electrophoresis – frontal analysis (CE-FA). Apparent Kb values were obtained by nonlinear regression analysis. The Kb of HSA-drug and gHSA-drug were compared. The Kb values of glycated form were lower than nonglycated albumin. This modification influences strenght of binding between gHSA and antibiabetc drugs. |
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