Organometallic Half-Sandwich Dichloridoruthenium(II) Complexes with 7-Azaindoles: Synthesis, Characterization and Elucidation of Their Anticancer Inactivity against A2780 Cell Line
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Plos one |
| MU Faculty or unit | |
| Citation | |
| Web | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143871 |
| Doi | http://dx.doi.org/10.1371/journal.pone.0143871 |
| Field | Biochemistry |
| Keywords | CRYSTAL-STRUCTURES; IN-VITRO; NAMI-A; RUTHENIUM; CYTOTOXICITY; LIGANDS; METALS; INTERCALATION; DERIVATIVES; DRUG |
| Attached files | |
| Description | A series of organometallic half-sandwich dichloridoruthenium(II) complexes of the general formula [Ru(eta(6)-p-cym)(naza)Cl-2] (1-8; p-cym = p-cymene; naza = 7-azaindole or its derivatives) was synthesised and fully characterized by elemental analysis, mass spectrometry, and infrared and multinuclear NMR spectroscopy. A single-crystal X-ray structural analysis of [Ru(eta(6)-p-cym)(2Me4Claza)Cl-2] (6) revealed a typical piano-stool geometry with an N7-coordination mode of 2-methyl-4-chloro-7-azaindole (2Me4Claza). The complexes have been found to be inactive against human ovarian cancer cell line A2780 up to the highest applied concentration (IC50 > 50.0 mu M). An inactivity of the complexes is caused by their instability in water-containing solvents connected with a release of the naza N-donor ligand, as proved by the detailed H-1 NMR, mass spectrometry and fluorescence experiments. |
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