Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
| Authors | |
|---|---|
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | PARKINSONISM & RELATED DISORDERS |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S1353802015003818 |
| Doi | http://dx.doi.org/10.1016/j.parkreldis.2015.09.006 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Parkinson's disease; Functional connectivity; Speech prosody; fMRI; Resting state; Dopaminergic; Levodopa; Acoustic; Motor speech network; Caudate nucleus |
| Description | Background: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. Methods: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. Results: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. Conclusions: We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found. (C) 2015 Elsevier Ltd. All rights reserved. |
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