Disseminated fusariosis by Fusarium proliferatum in a patient with aplastic anaemia receiving primary posaconazole prophylaxis - case report and review of the literature

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Authors	ŘÍČNÁ Dita LENGEROVÁ Martina PALACKOVÁ Martina HADRABOVÁ Markéta KOCMANOVÁ Iva WEINBERGEROVÁ Barbora PAVLOVSKÝ Zdeněk VOLFOVÁ Pavlína BOUCHNEROVÁ Jana MAYER Jiří RÁČIL Zdeněk
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Mycoses
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://dx.doi.org/10.1111/myc.12421
Doi	http://dx.doi.org/10.1111/myc.12421
Field	Oncology and hematology
Keywords	Fusariosis; Fusarium proliferatum; PCR diagnostics; Real-time PCR
Attached files	EL_1321740.pdf
Description	Disseminated fusariosis is a life-threatening, invasive, opportunistic infection in immunocompromised patients, especially those with haematological malignancies. The prognosis is poor because these fungi are resistant to many of the available antifungal agents. We present a case of disseminated fusariosis caused by Fusarium proliferatum in a patient with severe aplastic anaemia complicated by a secondary infection of Aspergillus flavus, with a fatal outcome. We also review the documented Fusarium infections in immunocompromised hosts.
Related projects:	Nové přístupy ve výzkumu, diagnostice a terapii hematologických malignit II CZECRIN - Český národní uzel Evropské sítě infrastruktur klinického výzkumu