Addenbrooke's Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson's Disease

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Authors	BERÁNKOVÁ Dagmar JANOUŠOVÁ Eva MRAČKOVÁ Martina ELIÁŠOVÁ Ilona KOŠŤÁLOVÁ Milena SKUTILOVÁ Světlana REKTOROVÁ Irena
Year of publication	2015
Type	Article in Periodical
Magazine / Source	Parkinson’s Disease
MU Faculty or unit	Faculty of Medicine
Citation
Web	http://www.hindawi.com/journals/pd/2015/579417/
Doi	http://dx.doi.org/10.1155/2015/579417
Field	Neurology, neurosurgery, neurosciences
Keywords	REVISED ACE-R; DIAGNOSTIC-CRITERIA; IMPAIRMENT; DEMENTIA; VALIDATION; ACCURACY; UTILITY; COHORT
Attached files	1319699_Addenbrooke_s_Cognitive.pdf ZVV_2015_145_1319699_Addenbrooke_s.pdf
Description	Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke's Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson's disease (PD) with normal cognition (PD-NC) and PD withmild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.
Related projects:	CEITEC - Central European Institute of Technology Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci