Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells
| Title in English | Creating life in 3D conference |
|---|---|
| Authors | |
| Year of publication | 2015 |
| MU Faculty or unit | |
| Citation | |
| Description | Superparamagnetic iron oxide nanoparticles have become a useful tool in biomedicine. Their applications include cell labelling for magnetic resonance imaging, drug and gene delivery and cell targeting. Targeting cells to a specific location is a first step in development of regenerative cellular therapy. To provide optimal dispersion, increase nanoparticle intake and minimize toxic effects Fe2O3 nanoparticles are often coated with different types of organic materials including citrate, dextran, albumin, starch polyethylene glycol or dimercaptosuccinic acid. However, magnetism of the nanoparticles decreases with diameter of the coating. Recently, the gamma-Fe2O3 nanoparticles were synthesized in gas phase by microwave plasma torch without any surfactants and additives. Therefore, this technology can open new perspectives for bioapplications. We studied interaction of different cell cultures including pluripotent cells with microwave-torch gamma-e2O3 nanoparticles. Our data indicate that these nanoparticles have minimal toxic effects and can be used in regenerative medicine. |
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