Determination of binding constants of selected sulfonylureas drugs
| Authors | |
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| Year of publication | 2014 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The strength of the interaction has a significant effect on biological activity of the drug. Various sulfonylureas (antidiabetic drugs) may induce hypoglycemia as a result of excesses in insulin production and release. Therefore, it is important to understand in detail the pharmacokinetics and pharmacodynamics of these drugs. The main objectives of this study were to determine the binding constants of the selected sulfonylurea drug (tolbutamide, chlorpropamide) with HSA using capillary electrophoresis – in physiological conditions. |
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