Nucleases in homologous recombination as targets for cancer therapy
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | FEBS Letters |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.febslet.2014.06.010 |
| Field | Genetics and molecular biology |
| Keywords | Genomic integrity; Homologous recombination; Nuclease; Inhibitor; Cancer therapy |
| Description | Genomic DNA is constantly challenged from endogenous as well as exogenous sources. The DNA damage response (DDR) mechanism has evolved to combat these challenges and ensure genomic integrity. In this review, we will focus on repair of DNA double-strand breaks (DSB) by homologous recombination and the role of several nucleases and other recombination factors as suitable targets for cancer therapy. Their inactivation as well as overexpression have been shown to sensitize cancer cells by increasing toxicity to DNA-damaging agents and radiation or to be responsible for resistance of cancer cells. These factors can also be used in targeted cancer therapy by taking advantage of specific genetic abnormalities of cancer cells that are not present in normal cells and that result in cancer cell lethality. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
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