Analyzing the defense strategies of Staphylococcus aureus strains against polyvalent bacteriophages

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Authors	VARGA Marian ZOUHAROVÁ Monika PANTŮČEK Roman MOŠA Marek DOŠKAŘ Jiří
Year of publication	2014
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and inovative antimicrobial strategies. One of them is phage therapy that represents a promising alternative to the use of antibiotics for combating bacterial infections. Some strains, however, are resistant to therapeutic bacteriophages, which may decrease the effectivity of phage-based drugs. In our study, we analyzed causes responsible for this resistance, mainly: (i) efficacy of phage adsorption to bacterial cells; (ii) interference with the products of the prophage-borne genes in lysogenic strains; and (iii) effect of CRISPR-Cas elements.
Related projects:	Výzkum stafylokokových bakteriofágových mutant s širokým spektrem hostitelů Partnerství a sítě pro spolupráci v experimentální biologii Centrum experimentální biomedicíny