Method of detoxication of yperite by using haloalkane dehalogenases

Prokop,  Zbyněk; Damborský,  Jiří; Opluštil, F.; Fořtová,  Andrea; Nagata,  Yuji

Method of detoxication of yperite by using haloalkane dehalogenases

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Authors	PROKOP Zbyněk DAMBORSKÝ Jiří OPLUŠTIL F. JESENSKÁ Andrea NAGATA Yuji
Year of publication	2012
Type	Patent
MU Faculty or unit	Faculty of Science
Publisher
State	Canada
Patent's number	CA 2610024
Description	Patent granted in Canada "Method of detoxication of yperite by using haloalkane dehalogenases".The method of detoxification of yperite by the use of haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contain at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are DhaA from Rhodococcus rhodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66 or LinB from Sphingomonas paucimobilis UT26. Decontamination is utilized for detoxification of yperite from the surfaces of instrumentality, constructional objects, the people’s or animal’s skin and elements of environment, when yperite is exposed to the action of decontamination composition at +10 C to +70 C, preferably at +40 C and pH = 4 to 12.
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