ISOQUINOLINE ALKALOIDS OF THE CZECH AND CHINESE CULTURE OF MACLEAYA MICROCARPA (MAXIM.) FEDDE
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | CHEMICKE LISTY |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.chemicke-listy.cz/docs/full/2013_s3_s420-s453.pdf |
| Field | Biochemistry |
| Keywords | ISOQUINOLINE ALKALOIDS; MACLEAYA MICROCARPA |
| Attached files | |
| Description | Macleaya microcarpa (Maxim.) Fedde belongs, together with M. cordata (Willd.) R. Br. and their interspecific hybrid Macleaya x kewensis Turill, to the genus Macleaya, family Papaveraceae. Quaternary benzophenanthridine alkaloids (QBAs) sanguinarine (SA), chelerythrine (CHE), chelirubine (CR), chelilutine (CL) and the rarely occurring macarpine (MA) are the most interesting bioactive substances. While the major benzophenanthridine alkaloids SA and CHE are available commercially and have been the subjects of numerous biological studies, minor QBAs remained unnoticed for a long time due to their limited availability. Not long ago, first biological studies described the effects of these alkaloids on cells and identified a number of interesting properties, which puts these alkaloids in the center of interest for further research. Minor QBAs display strong anti-proliferative and apoptotic activity in vitro. MA has been reported as promising fluorescent probe for cell nuclei labeling and visualization of various stages of the cell cycle in fluorescence microscopy and flow cytometry. In addition, polycyclic, planar structure of the quaternary form allows intercalation of these alkaloids into DNA. |
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