Is increased resistance of colorectal carcinoma cells to cytotoxic agents caused by the c-Myb-dependent activation of p38MAPK and PI3K/Akt signaling pathways?
| Authors | |
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| Year of publication | 2013 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Patients with colorectal carcinomas exhibiting upregulated c-Myb expression have poor prognosis. The aim of our study was to clarify the role of c-Myb in control of the cell death/survival of colorectal carcinoma cells treated with cytotoxic agents. We showed by flow cytometric analysis of cell viability that c-Myb reduced sensitivity of colorectal carcinoma cells to cisplatin and doxorubicin. We found increased level of the phosphorylated p38MAPK and Akt kinases in cells overexpressing c-Myb. We used selective inhibitors of these kinases and we found that increased resistance of colorectal carcinoma cells to cisplatin is caused by c-Myb-dependent activation of p38MAPK signaling pathway. |
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