New Laser Desorption Sample Introduction Techniques for Inductively Coupled Plasma Mass Spectrometry
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | New techniques for determination of trace elements in submicroliter sample volumes, substrate-assisted laser desorption (SALD)1,2 and diode laser thermal vaporization (DLTV)3 inductively-coupled plasma mass spectrometry (ICP-MS) will be presented. In summary, the both SALD and DLTV ICP-MS are suitable for quantitative elemental analysis of low-volume samples (typically 100 – 500 nL) and represent an alternative to nebulizers. Ad-vantages are also easy archiving, transportation, prearrangement of calibration sets and high through-put due to minimization of memory effects. In addition, biological samples, such as metalloproteins or metal complexes can be analyzed in other detection modes (MALDI-MS or fluorescence) from the same sample, which can provide supplementary information, e.g. protein mass or identity. |
| Related projects: |