High resolution structure of Aleuria aurantia lectin mutant reveals the principal of increased affinity

Houser,  Josef; Romano, Patrick; Wimmerová,  Michaela

High resolution structure of Aleuria aurantia lectin mutant reveals the principal of increased affinity

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Authors	HOUSER Josef ROMANO Patrick WIMMEROVÁ Michaela
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Mutant of Aleuria aurantia lectin with increased affinity towards 1-6 bound fucose was prepared. We prepared protein crystals and collected high quality data. Solved structure revealed the principal of the binding, shading the light upon variability of lectin binding sites.
Related projects:	Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs Lectins from human pathogens - structure, function, engineering Molekulární a strukturní biologie vybraných cytostatik. Od mechanických studií k chemoterapii rakoviny CEITEC - Central European Institute of Technology SYLICA - Synergies of Life and Material Sciences to Create a New Future