Speeding up Mass Spectrometry Imaging with fast Precision Mirror Scanning

• Authors: BEDNAŘÍK Antonín; KUBA Pavel; HOUŠKA Pavel; TOMALOVÁ Iva; MOSKOVETS Eugene; PREISLER Jan
• Year of publication: 2012
• Type: Article in Proceedings
• Conference: CECE 2012
• MU Faculty or unit: Central European Institute of Technology
• Web: http://www.ce-ce.org/cece2012/Proceedings%20CECE%202012%20Final+late%20abstracts_web.pdf
• Field: Analytic chemistry
• Keywords: mass spectrometry imaging; MALDI TOF MSI
• Description: MALDI mass spectrometry imaging (MALDI MSI) is one of the most rapidly evolving techniques in the field of mass spectrometry. This technique holds a great potential in biomarker discovery, drug distribution analysis and in biosciences generally. Hand in hand with new and more demanding applications a need of new high-throughput instrumentation arises. Though a 1 kHz lasers generation of mass spectrometers brought significant decrease of MSI time, a single high resolution image (10 000 pixels) acquisition can still consume many hours. Here we introduce an incorporation of a high speed scanning mirror redirecting the desorbing laser as a possible way to increase the MSI performance.

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