Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Journal of the Peripheral Nervous System |
| MU Faculty or unit | |
| Citation | |
| Web | http://onlinelibrary.wiley.com/doi/10.1111/j.1529-8027.2012.00420.x/abstract;jsessionid=ACC2AEE4796DC27669E2D4B624D02919.d03t04 |
| Doi | http://dx.doi.org/10.1111/j.1529-8027.2012.00420.x |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | diabetic neuropathy; prediabetes; small-fibre neuropathy; subclinical neuropathy; type 2 diabetes mellitus |
| Attached files | |
| Description | The aim of this study was to investigate the characteristics of prediabetes (preDM) and early (less than 3 years) diabetes mellitus type 2 (eDM2)-associated neuropathy and the value of recently proposed diagnostic criteria for diabetic sensorimotor polyneuropathy (DSPN). A prospective case-control study in a group of 48 consecutive patients with eDM2, 16 preDM patients and 40 age- and sex-matched normoglycaemic controls was performed. Clinical and laboratory diagnostic tests were used to detect neuropathic abnormalities; these were further classified in terms of recent diagnostic criteria. Criteria for confirmed DSPN based on abnormal nerve conduction (NC) studies were met in 7 (14.6%) eDM2 patients compared to no control, and the proportion significantly increased to 37.5% compared to 2.5% controls, if intraepidermal nerve fibre density (IENFD) was used as an alternative criterion in addition to NC. The subclinical DSPN criteria based on NC abnormalities were met in 4.2% eDM2 patients, while the proportion of preDM and eDM2 cases with subclinical sensory small-fibre involvement documented by IENFD reached 12.5% and 22.9% compared with 2.5% controls (p = 0.005 for eDM2). The absolute IENFD values from distal leg were significantly lower in both eDM2 and preDM patients (p = 0.005) compared to controls. Neuropathy associated with preDM/eDM2 predominantly involves sensory small fibres. |
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