Circular Dichroism Spectroscopy of DNA: From Duplexes to Quadruplexes

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Authors

VORLÍČKOVÁ Michaela KEJNOVSKÁ Iva BEDNÁŘOVÁ Klára RENČIUK Daniel KYPR Jaroslav

Year of publication 2012
Type Article in Periodical
Magazine / Source Chirality
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.ncbi.nlm.nih.gov/pubmed/22696273
Doi http://dx.doi.org/10.1002/chir.22064
Field Biophysics
Keywords circular dichroism; nucleic acid conformations; structural transitions; B form; A form; Z form; trinucleotide repeats; RNA
Attached files
Description Nucleic acids bear the genetic information and participate in its expression and evolution during replication, repair, recombination, transcription, and translation. These phenomena are mostly based on recognition of nucleic acids by proteins. The major factor enabling the specific recognition is structure. Circular dichroism (CD) spectroscopy is very useful to study secondary structures of nucleic acids, in general, and DNA, in particular. CD sensitively reflects isomerizations among distinct conformational states. The isomerizations may operate as molecular switches regulating various physiological or pathological processes. Here, we review CD spectra of nucleic acids, beginning with early studies on natural DNA molecules through analyses of synthetic polynucleotides to study of selected genomic fragments. Chirality 24:691698, 2012. (c) 2012 Wiley Periodicals, Inc.
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