Project information
Methods for measurement of mechanical forces on cell and tissue scale in organoids

Information

This project doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official project website can be found on muni.cz.
Project Identification
MUNI/11/SUP/06/2022
Project Period
1/2022 - 12/2022
Investor / Pogramme / Project type
Masaryk University
MU Faculty or unit
Faculty of Medicine

Together with chemical signals, mechanical forces form an integral part of mechanisms governing tissue morphogenesis, homeostasis, and function, and aberrations in mechanosignaling lead to developmental defects and disease. Quantitative measurements of cell and tissue mechanical properties are essential to understand a wide variety of biological phenomena, and to decipher principles of development and cancer. In this project, we will develop protocols for mechanical force quantification in organoid cultures, including micropipette aspiration assay and laser ablation. Harnessing these powerful tools will license us to entry the domain of mechanobiology and provide necessary preliminary data for further hypothesis development and applications to external grant agencies.

Publications

Total number of publications: 1


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