Project information
Characterization of intrinsically disordered proteins

Information

This project doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

GF20-05789L

Project Period

1/2020 - 12/2022

Investor / Pogramme / Project type

Czech Science Foundation

LA Grants

MU Faculty or unit

Central European Institute of Technology

doc. RNDr. Mgr. Jozef Hritz, Ph.D.

Cooperating Organization

Universität für Bodenkultur Wien

Responsible person Chris Oostenbrink

We will characterize the conformational ensembles of RD-TyrH, Map2c and tau. We hypothesize that shifts in the conformational ensembles of these IDPs/IDRs are crucial to understand their function and will further develop integrative experimental and computational approaches to characterize these shifts.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Publications

Total number of publications: 21

2024

dGAE(297-391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy-Like Tau Filaments

KITOKA Kristine LENDS Alons KUČINSKAS Gytis BULA Anna Lina KRASAUSKAS Lukas SMIRNOVAS Vytautas ZILKOVA Monika KOVACECH Branislav SKRABANA Rostislav HRITZ Jozef JAUDZEMS Kristaps

Article in Periodical

Angewandte Chemie International Edition, year: 2024, DOI
Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3zeta protein variants

CRHA Radek KOZELEKOVÁ Aneta HOFROVÁ Alena IĽKOVIČOVÁ Lucia GAŠPARIK Norbert KADEŘÁVEK Pavel HRITZ Jozef

Article in Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2024, volume: 266, edition: Pt 2, DOI
How does phosphorylation affect interaction between 14-3-3ζ and Tau proteins?

KOZELEKOVÁ Aneta IĽKOVIČOVÁ Lucia CRHA Radek HOFROVÁ Alena HRITZ Jozef

Conference abstract

Year: 2024, type: Conference abstract

2023

14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding

KOZELEKOVÁ Aneta IĽKOVIČOVÁ Lucia CRHA Radek HOFROVÁ Alena HRITZ Jozef

Conference abstract

Year: 2023, type: Conference abstract
Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region

LASORSA Alessia BERA Krishnendu MALKI Idir DUPRE Elian CANTRELLE Francois-Xavier MERZOUGUI Hamida SINNAEVE Davy HANOULLE Xavier HRITZ Jozef LANDRIEU Isabelle

Article in Periodical

Biochemistry, year: 2023, volume: 62, edition: 11, DOI
Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation

BERA Krishnendu LANDRIEU Isabelle HRITZ Jozef

Conference abstract

Year: 2023, type: Conference abstract
Designing of Insecticides Against Bemisia tabaci targeting ecdysone receptor

BERA Krishnendu HRITZ Jozef BRÁZDA Václav KUMAR Rajesh BERA Krishnendu

Conference abstract

Year: 2023, type: Conference abstract
Interaction of selected drugs at dimer interface of human 14-3-3ζ protein

BERA Krishnendu HRITZ Jozef

Conference abstract

Year: 2023, type: Conference abstract
Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide

BERA Krishnendu ALESSIA Lasorsa LANDRIEU Isabelle HRITZ Jozef ALESSIA Lasorsa HRITZ Jozef

Conference abstract

Year: 2023, type: Conference abstract

2022

14-3-3 protein isoforms: mutual dimerization propensities screening kit

ŠIMEK Jan KRÁLOVÁ Kateřina HRITZ Jozef

Conference abstract

Year: 2022, type: Conference abstract