Project information
Alternative mechanisms of deregulation of the p53 pathway in chronic lymphocytic leukemia

Information

This project doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

GA19-15737S (kod CEP: GA19-15737S)

Project Period

1/2019 - 6/2022

Investor / Pogramme / Project type

Czech Science Foundation

Standard Projects

MU Faculty or unit

Central European Institute of Technology

prof. RNDr. Šárka Pospíšilová, Ph.D.
Mgr. Veronika Mančíková, Ph.D.

Cooperating Organization

University Hospital Brno-Bohunice

Eventually almost all cancers escape the tumor suppression control by the key genome guardian p53, most frequently by genetic mutations but also by other mechanisms. Defects in p53 are widely accepted to be the most significant marker of poor prognosis among chronic lymphocytic leukemia (CLL) patients. We hypothesize that apart from a direct genetic impairment, other mechanisms acting upon p53 protein could be driving CLL. Therefore, we plan to portray the landscape of phosphorylation modifications of p53 in primary human CLL cells treated with a clinically relevant drug set. We anticipate to identify differences among patients with distinct genetic background and with diverse clinical outcome.

Publications

Total number of publications: 15

2023

Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in the activation of circumjacent pathways upon DNA damage

MANČÍKOVÁ Veronika PEŠOVÁ Michaela PAVLOVÁ Šárka HELMA Robert ZÁVACKÁ Kristýna HEJRET Václav TAUŠ Petr HYNŠT Jakub PLEVOVÁ Karla MALČÍKOVÁ Jitka POSPÍŠILOVÁ Šárka

Article in Periodical

MOLECULAR ONCOLOGY, year: 2023, volume: 17, edition: 1, DOI

2022

Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage

PEŠOVÁ Michaela MANČÍKOVÁ Veronika HELMA Robert PAVLOVÁ Šárka HEJRET Václav TAUŠ Petr HYNŠT Jakub PLEVOVÁ Karla KOTAŠKOVÁ Jana MALČÍKOVÁ Jitka POSPÍŠILOVÁ Šárka

Conference abstract

Year: 2022, type: Conference abstract
Distinct p53 phospohrylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage.

PEŠOVÁ Michaela MANČÍKOVÁ Veronika HELMA Robert PAVLOVÁ Šárka HEJRET Václav TAUŠ Petr HYNŠT Jakub PLEVOVÁ Karla KOTAŠKOVÁ Jana MALČÍKOVÁ Jitka POSPÍŠILOVÁ Šárka

Conference abstract

Year: 2022, type: Conference abstract
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes

OLBERTOVÁ Helena PLEVOVÁ Karla PAVLOVÁ Šárka MALCIKOVA Jitka KOTAŠKOVÁ Jana STRÁNSKÁ Kamila ŠPUNAROVÁ Michaela TRBUŠEK Martin NAVRKALOVÁ Veronika DVOŘÁČKOVÁ Barbara TOM Nikola PÁL Karol JAROŠOVÁ Marie BRYCHTOVÁ Yvona PANOVSKÁ Anna DOUBEK Michael POSPÍŠILOVÁ Šárka

Article in Periodical

BMC Cancer, year: 2022, volume: 22, edition: 1, DOI

2021

Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study

SUTTON L.A. LJUNGSTROM V. ENJUANES A. CORTESE D. SKAFTASON A. TAUSCH E. STAŇO KOZUBÍK Kateřina NADEU F. ARMAND M. MALČÍKOVÁ Jitka PANDZIC T. FORSTER J. DAVIS Z. OSCIER D. ROSSI D. GHIA P. STREFFORD J.C. POSPÍŠILOVÁ Šárka STILGENBAUER S. DAVI F. CAMPO E. STAMATOPOULOS K. ROSENQUIST R.

Article in Periodical

haematologica, year: 2021, volume: 106, edition: 3, DOI
Fosforylace proteinu p53: vliv na aktivitu dráhy p53 po poškození DNA u chronické lymfocytární leukémie.

PEŠOVÁ Michaela MANČÍKOVÁ Veronika PAVLOVÁ Šárka HELMA Robert MALČÍKOVÁ Jitka ŽENATOVÁ Marcela HEJRET Václav TAUŠ Petr KOTAŠKOVÁ Jana PLEVOVÁ Karla DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka

Conference abstract

Year: 2021, type: Conference abstract
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

DOFFE Flora CARBONNIER Vincent TISSIER Manon LEROY Bernard MARTINS Isabelle MATTSSON Johanna S. M. MICKE Patrick PAVLOVÁ Šárka POSPÍŠILOVÁ Šárka ŠMARDOVÁ Jana JOERGER Andreas C. WIMAN Klas G. KROEMER Guido SOUSSI Thierry

Article in Periodical

Cell Death and Differentiation, year: 2021, volume: 28, edition: 5, DOI
Klinický dopad a evoluce minoritních TP53-mutovaných klonů v kontextu různých terapeutických režimů u CLL.

MALČÍKOVÁ Jitka PAVLOVÁ Šárka KUNT VONKOVÁ Barbara RADOVÁ Lenka PLEVOVÁ Karla KOTAŠKOVÁ Jana PÁL Karol DVOŘÁČKOVÁ Barbara ŽENATOVÁ Marcela HYNŠT Jakub ONDROUŠKOVÁ Eva PANOVSKÁ Anna MAŠLEJOVÁ Stanislava BEZDĚKOVÁ Lucie ZUCHNICKÁ J. URBANOVÁ R. LYSÁK Daniel NOVÁK J. BREJCHA Martin DOUBEK Michael

Conference abstract

Year: 2021, type: Conference abstract
Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options

MALČÍKOVÁ Jitka PAVLOVÁ Šárka KUNT VONKOVÁ Barbara RADOVÁ Lenka PLEVOVÁ Karla KOTAŠKOVÁ Jana PÁL Karol DVOŘÁČKOVÁ Barbara ŽENATOVÁ Marcela HYNŠT Jakub ONDROUŠKOVÁ Eva PANOVSKÁ Anna BRYCHTOVÁ Yvona ZÁVACKÁ Kristýna TICHÝ Boris TOM Nikola MAYER Jiří DOUBEK Michael POSPÍŠILOVÁ Šárka

Article in Periodical

Blood, year: 2021, volume: 138, edition: 25, DOI
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma

LOBELLO Cosimo TICHÝ Boris BYSTRÝ Vojtěch RADOVÁ Lenka FILIP Daniel MRÁZ Marek MONTES-MOJARRO I.A. PROKOPH N. LAROSE H. LIANG H.C. SHARMA G.G. MOLOGNI L. BELADA D. KAMARADOVA K. FEND F. GAMBACORTI-PASSERINI C. MERKEL O. TURNER Suzanne Dawn JANÍKOVÁ Andrea POSPÍŠILOVÁ Šárka

Article in Periodical

Leukemia, year: 2021, volume: 35, edition: 5, DOI