Project information
European Human Biomonitoring Initiative
(HBM4EU)
- Project Identification
- 733032
- Project Period
- 1/2017 - 6/2022
- Investor / Pogramme / Project type
-
European Union
- Horizon 2020
- Health, demographic change and wellbeing (Societal Challenges)
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jana Klánová, Ph.D.
- Mgr. Ondřej Adamovský, Ph.D.
- Lola Murielle Bajard ép.Esner, Ph.D.
- prof. RNDr. Luděk Bláha, Ph.D.
- doc. RNDr. Pavel Čupr, Ph.D.
- Elena Dominguez Romero, PhD.
- Mgr. Klára Komprdová, Ph.D.
- Ing. Štěpán Koudelka, Ph.D.
- RNDr. Ondřej Májek, Ph.D.
- Lisa Emily Melymuk, Ph.D.
- Chander Kant Negi, Ph.D.
- Mgr. Ondřej Ngo, Ph.D.
- Ing. Šárka Palátová, Ph.D.
- Veronika Janina Schacht, Ph.D.
- Mgr. Libor Šulc, Ph.D.
- Jakub Vinkler, DiS.
- Chiara Maria Vitale, PhD
- Cooperating Organization
-
Institute of Experimental Medicine of the ASCR, v. v. i.
- Responsible person MUDr. Radim Šrám, DrSc.
- Responsible person prof. MUDr. Milena Králíčková, Ph.D.
- Responsible person prof. Ing. Jana Hajšlová, CSc.
- Responsible person Ing. Adéla Fraňková, Ph.D.
- Responsible person Gorazd B. Stokin
- Responsible person RNDr. Ondřej Májek, Ph.D.
- Responsible person Marike Kolossa-Gehring
The overarching goal of the European Human Biomonitoring Initiative is to generate knowledge to inform the safe management of chemicals and so protect human health. We will use human biomonitoring to understand human exposure to chemicals and resulting health impacts and will communicate with policy makers to ensure that our results are exploited in the design of new chemicals policies and the evaluation of existing measures.
Key objectives include:
- Harmonizing procedures for human biomonitoring across 26 countries, to provide policy makers with comparable data on human internal exposure to chemicals and mixtures of chemicals at EU level;
- Linking data on internal exposure to chemicals to aggregate external exposure and identifying exposure pathways and upstream sources. Information on exposure pathways is critical to the design of targeted policy measures to reduce exposure;
- Generating scientific evidence on the causal links between human exposure to chemicals and negative health outcomes; and
- Adapting chemical risk assessment methodologies to use human biomonitoring data and account for the contribution of multiple external exposure pathways to the total chemical body burden.
We will achieve these objectives by harmonizing human biomonitoring initiatives in 26 countries, drawing on existing expertise and building new capacities. By establishing National Hubs in each country to coordinate activities, we will create a robust Human Biomonitoring Platform at European level. This initiative contributes directly to the improvement of health and well-being for all age groups, by investigating how exposure to chemicals affects the health of different groups, such as children, pregnant women, foetuses and workers. We will also investigate how factor such as behavior, lifestyle and socio-economic status influence internal exposure to chemicals across the EU population. This knowledge will support policy action to reduce chemical exposure and protect
health.
Publications
Total number of publications: 51
2023
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Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
International Journal of Hygiene and Environmental Health, year: 2023, volume: 249, edition: April 2023, DOI
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Has Regulatory Action Reduced Human Exposure to Flame Retardants?
ENVIRONMENTAL SCIENCE & TECHNOLOGY, year: 2023, volume: 57, edition: 48, DOI
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Identification of Real-Life Mixtures Using Human Biomonitoring Data: A Proof of Concept Study
Toxics, year: 2023, volume: 11, edition: 3, DOI
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Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge
International Journal of Hygiene and Environmental Health, year: 2023, volume: 249, edition: April 2023, DOI
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Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2 '-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women
International Journal of Hygiene and Environmental Health, year: 2023, volume: 250, edition: May 2023, DOI
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Sugar-sweetened beverages and childhood abnormal adiposity in the Czech Republic - narrative literature review
CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH, year: 2023, volume: 31, edition: 1, DOI
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The Influence of Adiposity Levels on the Relation between Perfluoroalkyl Substances and High Depressive Symptom Scores in Czech Adults
Toxics, year: 2023, volume: 11, edition: 11, DOI
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Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe
Toxics, year: 2023, volume: 11, edition: 10, DOI
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Time-trends in human urinary concentrations of phthalates and substitutes DEHT and DINCH in Asian and North American countries (2009-2019)
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, year: 2023, volume: 33, edition: 2, DOI
2022
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A large scale multi-laboratory suspect screening of pesticide metabolites in human biomonitoring: From tentative annotations to verified occurrences
Environment International, year: 2022, volume: 168, edition: October 2022, DOI